A biocompatible approach to surface modification: Biodegradable polymerfunctionalized super-paramagnetic iron oxide nanoparticles
writer：Lin Sun, Chi Huang, Tao Gong, Shaobing Zhou ?
keywords：Super-paramagnetic,Biodegradation
source：期刊
specific source：Materials Science and Engineering C 30 (2010) 583–589
Issue time：2010年
In the study, Fe3O4 nanoparticles with a size range of 10–20 nm were firstly prepared by the modified
controlled chemical coprecipitation method from the solution of ferrous/ferric mixed salt-solution in alkaline
medium. Then, the super-paramagnetic iron oxide nanoparticles were covalently modified by biodegradable
polymers such as polyethylene glycol (PEG) and poly(ethylene glycol)-co-poly(d,l-lactide) (PELA). The size
and its distribution of the nanoparticles were determined by dynamic light scattering measurements (DLS).
The magnetic nanoparticles was characterized by X-ray powder diffraction (XRD), transmission electron
microscopy (TEM), electron diffraction (ED), Fourier transform infrared spectroscopy (FT-IR) and UV–visible
spectrophotometry (UV). Magnetic properties were measured using a vibrating sample magnetometer. And
the 5-dimethylthiazol-2-yl-2,5-diphenyltetrazolium bromide (MTT) assay was performed to evaluate the
biocompatibility of the magnetic nanoparticles. The results showed that the Fe3O4 nanoparticles
functionalized by PEG and PELA possessed a mean size of 43.2 and 79.3 nm, respectively, and exhibited
an excellent biocompatibility.