【Adv Healthc Mater】Salt Triggered Adaptive Dissociation Coating with Dual Effect of Antibacteria and Anti-multiple Encrustations in Urological Devices
writer：Huan Yu, Hengchong Shi*, Lei Wang, Shifang Luan, Dianpeng Qi*, Xiaodong Chen*, et al
keywords：Urological devices-related infection, Infectious encrustation, Metabolic encrustation, Non-leachable coating, Biocompatibility
source：期刊
specific source：Advanced Healthcare Materials
Issue time：2023年
Bacterial infection and multiple encrustations are life-threatening complications for patients implanted with urological devices. Limited by time-consuming procedures and substrate dependence, current strategies are difficult to prevent the aforementioned complications simultaneously. Herein, we report the design of a salt-triggered chondroitin sulfate complex (CS/Si-N+) coating with adaptive dissociation, which realized the dual functions of antibacteria and anti-multiple encrustations in urological devices with arbitrary shapes. The existence of covalent interaction for complex itself and interface ensured the formation of robust coating, especially in various harsh environments. Meanwhile, benefiting from adaptive dissociation of the ion pairs in the CS/Si-N+ coating under urine electrolytes, the exposed ion groups and enhanced hydrophilicity were more conducive to the inhibition of bacterial infection and multiple encrustations simultaneously. The coating achieved the broad-spectrum bactericidal effect, especially methicillin-resistant Staphylococcus aureus. As a proof of concept, in a simulated metabolic encrustation model, the coating exhibited significant advantages in resisting calcium oxalate encrustation with reduction of the calcium content by over 90%. Also, this non-leachable and all-in-one coating shows good biocompatibility in a pig in vivo model. Such coating strategy is expected to be a practicable approach to prevent the urological medical devices related complications.