【Nature Communications】Heparin-network-mediated long-lasting coatings on intravascular catheters for adaptive antithrombosis and antibacterial infection
作者：Lin Liu#, Huan Yu#, Lei Wang, Jinghua Yin, Shifang Luan*, Hengchong Shi*, et al
關鍵字：antithrombosis, antibacterial infection, biomedical catheter
論文來源：期刊
發表時間：2023年
Bacteria-associated infections and thrombosis, particularly catheter-related bloodstream infections and catheter-related thrombosis, are life-threatening complications. Herein, we utilize a concise assembly of heparin sodium with organosilicon quaternary ammonium surfactant to fabricate a multifunctional coating complex. In contrast to conventional one-time coatings, the complex attaches to medical devices with arbitrary shapes and compositions through a facile dipping process and further forms robust coatings to treat catheterrelated bloodstream infections and thrombosis simultaneously. Through their robustness and adaptively dissociation, coatings not only exhibit good stability under extreme conditions but also significantly reduce thrombus adhesion by 60% and broad-spectrum antibacterial activity (> 97%) in vitro and in vivo. Furthermore, an ex vivo rabbit model verify that the coated catheter has the potential to prevent catheter-related bacteremia during implantation. This substrate-independent and portable long-lasting multifunctional coating can be employed to meet the increasing clinical demands for combating catheterrelated bloodstream infections and thrombosis.