Antisolvent Crystallization of Biapenem: Estimation of Growth and Nucleation Kinetics
writer：Yang-Hui Luo, Guo-Gan Wu, and Bai-Wang Sun*
keywords：ATR-FTIR, FBRM, PVM, Nucleation
source：期刊
Issue time：2013年
A process mathematic model of seed batch desupersaturation experiments and induction time experiments for the investigation of growth and nucleation kinetics of
biapenem through an antisolvent procedure in water/ethanol (antisolvent) system was developed in this work. The kinetic parameters for growth and nucleation were estimated by using in situ technology: attenuated total re?ection Fourier transform infrared (ATR-FTIR) spectroscopy for solute concentration, focused beam re?ectance measurement (FBRM) for CLD moments, and particle vision and measurement (PVM)
for particle image measurement. The challenging aspect for the development of this model was the recovery of crystal size distributions (CSDs) from the chord length distribution (CLD) moments; batch experiments were designed for the estimation of this relationship. The mathematic model in this work was con?rmed by a comparison between model predictions and experimental data.