Biomimetic nanofibers can construct effective tissue-engineered intervertebral discs for therapeutic implantation
writer：Junchuan Yang,b Xinglong Yang,c Le Wang, Wei Zhang,d Wenbo Yu,b Nuoxin Wang,b Baogan Peng,d Wenfu Zh
keywords：Biomimetic nanofibers
source：期刊
specific source：Nanoscale，DOI: 10.1039/c7nr03944a
Issue time：2017年
We present a total tissue engineered (TE) intervertebral disc (IVD) to address IVD degradation, which is a major cause of chronic neck and back pain. The TE IVD is comprised of an alginate hydrogel-based nucleus pulposus (NP) and hierarchically organized, concentric ring-aligned electrospun (ES) polycaprolactone (PCL)/poly (D,L-lactide-co-glycolide) (PLGA)/Collagen type I (PPC)-based annulus fibrosus (AF). The TE IVD exhibits excellent hydrophilicity to simulate highly hydrated native IVD. Long-term in vivo implantation assays demonstrate the excellent structural (shape maintenance, hydration, and integration with surrounding tissues) and functional (mechanical supporting and flexibility) performances of the TE IVD. Our study provides a novel approach for treating IVD degeneration.