(CCS Chem.) Optically Active Nucleobase-Functionalized Polynorbornenes Mimicking Double-Helix DNA
writer：Wang, L.; Lu, N.; Huang, S.; Wang, M.; Chen, X.; Yang, H.*
keywords：Polynorbornene
source：期刊
specific source：CCS Chemistry, 2020, 2, 1787-1796
Issue time：2020年
The development of synthetic polymers that mimic the double-stranded helical structure of DNA is a fascinating topic in polymer science. In this study, we designed and synthesized two chiral norbornene monomers containing adenine and thymine, which were mixed to form a hydrogen-bonding complementary complex, by which a ring-opening metathesis polymerization (ROMP) was performed. High-resolution transmission electron microscopy (HRTEM) undoubtedly showed the self-assembly of the optically active complementary nucleobasefunctionalized polynorbornenes into a double helix. Computer simulations and a two-dimensional nuclear Overhauser effect spectroscopy (2DNOESY) experiment showed that the doublestranded helical polynorbornene was derived from a copolymer of alternating adenine and thymine units.
Keywords: polynorbornene, chirality, nucleobase, hydrogen bond, double helix