Controlled PEGylation crowdedness for polymeric micelles to pursue ligand-specified privileges as nucleic acid delivery vehicles
writer：Chen Xiyi, Gu Haifeng, Yang Jinjun, Wu Sudong, Liu Jun, Yang Xi, Chen Qixian
keywords：polymeric micelle, PEGylation, cyclic RGD, mRNA delivery, endosome escape
source：期刊
specific source：ACS Applied Materials & Interfaces
Issue time：2017年
A facile poly(ethylene glycol) (PEG) detachment
scheme was utilized to control the PEGylation degree of the
polymeric micelles. The performance of cyclic Arg-Gly-Asp (cRGD)
as a targeted moiety was studied on a class of polymeric micelles with
various PEGylation degrees, revealing that the specific cRGDmediated
cell affinity, thus the cellular uptake and implicated privileges
including the ligand-specified favorable intracellular trafficking and
consequent favorable biofunctions, was prominent for the polymeric
micelles with high PEGylation degree. These results endow important
information and implications for the design and development of
targeted nanomedicine, particularly the delivery of vulnerable
biological compounds.