Supramolecular nanoparticles constructed by balancing the forces between attractive host–guest and repulsive electrostatic interactions in two positively charged polymers
writer：Zhuang YueZhu, Gu WenXing, Yang JinJun, Chen XiYi, Gao Hui
keywords：Supermolecule, Nanoparticles, Drug deliver
source：期刊
specific source：RSC Advances
Issue time：2015年
A novel type of supramolecular nanoparticle (SNP) was self-assembled based on the balance of forces including attractive supramolecular host–guest interactions and repulsive electrostatic interactions between the host and the guest polymers. b-cyclodextrin (CD) grafted positively charged or neutral poly(glycerol methacrylate) (P+CD or PCD) and negatively charged CD-modified poly(acrylic acid) (PAA– CD) were synthesized respectively as the host polymers. While 4-tert-butylphenyl group (TBP) grafted positive poly(glycerol methacrylate) (P+TBP) was synthesized as the guest polymer to study the influencen of electrostatics in the host guest systems between CD and TBP. The resulting P+CD/P+TBP SNPs, possessing good stability, will provide a guide for the future construction of SNPs and promote the development of SNPs as carriers for biomedical applications such as drug delivery agents.