作者：Guo Lamei, Yang Jinjun, Wang Hao, Yi Yu
關鍵字：self-assembly, nanomaterials, cancer immunotherapy
論文來源：期刊
具體來源：Molecules
發表時間：2023年
Advances in nanotechnology have brought innovations to cancer therapy. Nanoparticlebased
anticancer drugs have achieved great success from bench to bedside. However, insufficient
therapy efficacy due to various physiological barriers in the body remains a key challenge. To
overcome these biological barriers and improve the therapeutic efficacy of cancers, multistage selfassembled nanomaterials with advantages of stimuli-responsiveness, programmable delivery, and immune modulations provide great opportunities. In this review, we describe the typical biological barriers for nanomedicines, discuss the recent achievements of multistage self-assembled nanomaterials for stimuli-responsive drug delivery, highlighting the programmable delivery nanomaterials, in situ transformable self-assembled nanomaterials, and immune-reprogramming nanomaterials. Ultimately, we perspective the future opportunities and challenges of multistage self-assembled nanomaterials for cancer immunotherapy.