[Ind. Eng. Chem. Res.] A Facile Bifunctional Strategy for Fabrication of Bioactive or Bioinert Functionalized Organic Surfaces via Amides-initiated Photochemical Reactions
writer：Wu, Zhengfang; Wang, Dehui; Yang, Peng
keywords：Surface， Photograft，Polymer Brush，Bioinert，Bioactive
source：期刊
specific source：Industrial & Engineering Chemistry Research
Issue time：2014年
Organic polymeric materials would exploit excellent
potential in biomedical field if their interfacial problem could be fully
resolved. A necessary prerequisite to this purpose often involves in the simple but effective synthesis of
bioactive surface to endow polymer surfaces with high reactivity
towards efficient biomolecules conjugation and bioinert surface to prevent
non-specific adsorption of non-target biomolecules. Although the corresponding
research has been an important topic, actually few strategy could pave the way to
comprehensively and simply tackle both of bioactive and bioinert surfaces
preparation issues. Herein we reported an extremely simple and integrative
bifunctional method that could efficiently tailor organic material surface
towards both of bioactive and bioinert functions. This method is based on the
use of amides-initiated photochemical reaction in a confined space, which
depending on the type of solutes used, results in the incorporation
of primary amine groups or surface carbon radicals on inert polymer surface.
The grafted amine group could be used as highly reactive site for biomolecule
conjugation and the surface carbon radical could be used to initiate radical
graft polymerization of anti-fouling polymer brushes. We expect this simple but
powerful method could provide a general resolution to solve the interfacial
problem of organic substrate, offering a low-cost practical approach for real biomedical applications.