[J. Mater. Chem. B] Self-Assembled Proteinaceous Wound Dressings Attenuate Secondary Trauma and Improve Wound Healing In Vivo
作者：Jian Zhao, Yangcui Qu, Hong Chen, Rui Xu*, Qian Yu*, Peng Yang*
關鍵字：surface coating; lysozyme; disassembly; secondary trauma attenuation; wound healing
論文來源：期刊
具體來源：Journal of Materials Chemistry B
發(fā)表時間：2018年
A new type of wound dressing that can be easily peeled from the wound during frequent changes is essential in clinical application to reduce secondary trauma and relieve the pain patients suffered. Here, we discover that the phase-transitioned lysozyme nanofilm (PTLF) composing of self-assembled protein nanoparticles with amyloid-like structure inside can disassemble and detach from a substrate surface under stimuli of vitamin C solution. Accordingly, a stimuli-responsive gauze coated with this phase-transitioned lysozyme nanofilm (PTLF@gauze) is developed. This novel wound dressing PLTF@gauze is fabricated through a simple, universal and environmentally benign approach by immersing the pristine gauze in lysozyme phase transition aqueous solution for minutes. In comparison with pristine gauze, the PTLF@gauze can be peeled from the mouse wound with a smaller strength causing less secondary trauma, resulting from the disassembly and detachment of PTLF from gauze in presence of vitamin C, which is entirely different from the normal low-adherent wound dressing based on anti-fouling. Meanwhile, the PTLF@gauze accelerates wound closure using a murine wound healing model owing to the anti-infective capacity of PTLF. This work thus provides an effective surface modification method for medical devices and suggests great potential application of self-assembled proteinaceous coating in wound care.