Hollow double-layered polymer nanoparticles with S-nitrosothiols for tumor targeted therapy
writer：Tuanwei Liu, Jingjing Hu, X. Y. Ma, B. Kong, Jilan Wang, Zhide Zhang,* Dianshun Guo,* Xinlin Yang*
keywords：NO vehichle; tumor targeted delivery, S-nitrosothiol, Polymer microsphere
source：期刊
specific source：J Mater Chem B, 5 (36), 7519-7528 (2017). DOI: 10.1039/C7TB01715D
Issue time：2017年
Tumor targeted hollow double-layered polymer nanoparticle (HDPNs) with S-nitrosothiols for nitric mono-oxide (NO)-releasing as chemotherapy is described. Via a two-stage distillation precipitation co-polymerization, simple post-treatment and S-nitrosothiols modification, the S-nitroso HDPNs showed a pH and glucose dual responsiveness,
which is benefit for the accurate binding with the sialic acid over-expressed
cancer cells, providing prerequisites for the disulfide polymer assisted cell
taken-up, intracellular GSH induced decomposition and rapid NO release.
Confocal microscope and cytotoxicity assay with normal versus tumor cells
demonstrated the in vitro recognition, intracellular delivery ability and tumor cell targeting
cytotoxicity. Especially worth mentioning, the inevitable small amount of NO
leakage in the transmission will take part in normal physiological activities
and not cause serious side effects, providing a possible solution to avoid the
intolerable side effects of the traditional chemotherapy treatment for cancer.