Molecularly imprinted polymeric nanoparticles with S-nitrosothiols for cancer targeted therapy
writer：Liu, Tuanwei;Zhenyun Qiao, Ping Zhang, Zhide Zhang, Dianshun Guo, Xinlin Yang*
keywords：molecularly imprinted polymer, nitric oxide, target therapy, cancer, nanoparticle
source：期刊
specific source：Colloid Surf B,173 (1), 356-365 (2019). DOI: 10.1016/j.colsurfb.2018.09.078.
Issue time：2018年
The goal for cancer therapy is to specific targeting to tumors and efficient entry into cancer cell, avoiding the intolerable side effects. Herein, combining nitric oxide based chemotherapy and molecule-imprinting cell recognition technique, we design and synthesize a kind of sialic acid (SA) over-expressed tumor targeted hollow double layered SA imprinted polymer nanoparticles (MIPs) with S-nitrosothiols for NO releasing as chemotherapy. Equilibrium/selective bindings properties and probe experimental results imply that the MIPs have an intelligent selective binding to cancer cells featuring high levels of SA glyans. Cytotoxicity assay with kinds of cells confirms the intelligent in vitro recognition with SA over-expressed tumor cells, disulfide polymer assisted cell uptake,
intracellular GSH induced decomposition and rapid NO-releasing for trigger cell apoptosis. The inevitable small amount of NO leakage from S-nitroso MIPs will take part in normal physiological activities and not cause serious side effects. This kind of nitric oxide based chemotherapy and molecule-imprinting cell recognition technique might provide a solution for accurate therapy to various forms of cancer with specific markers and avoid the intolerable side effects of the traditional chemotherapy treatment.