Magnetic core-shell S-nitrosothiols nanoparticles as tumor dual-targeting theranostic platform
作者：Tuanwei Liu, Ping Zhang, Xiaoying Huang, Xiaoxuan Chi, Zinan Li, Zhide Zhang, Dian-Shun Guo, Xinlin
關鍵字：Nitric oxide, targeting theranostic, synergistic effect, core-shell magnetic nanoparticles
論文來源：期刊
具體來源：Colloid Surf. B 173 (1), 356-365 (2019). https://doi.org/10.1016/j.colsurfb.2019.05.075
發表時間：2019年
The external force guided targeting strategy, as well as the in vivo active targeting
strategy based on “ligands-receptors” on the targeting cells and tissues have attracted
much research interest. Herein, a kind of hyaluronic acid (HA) and folic acid (FA)
modified magnetic S-nitrosothiols core-shell nanoparticles for nitric oxide (NO)
control release as dual-tumor targeting theranostic platform were described,
combining the external guidance and internal active targeting properties. Confocal
microscopy assay and cells cytotoxicity experiments confirmed the active tumor cells
targeting recognition, cells uptake, and NO initiated cytotoxicity of the HA-FA
external functional layer modified S-nitrosothiols nanoparticles in vitro. In vivo
magnetic resonance imaging (MRI) characterization, bio-distribution assay in organs
and tumor, significant tumor inhibition efficacy, survival units of the mice bearing
tumor, as well as the systemic toxicity assay demonstrated the efficiency of
cooperative tumor targeting diagnosis and controlled NO-releasing chemotherapy. To
the best of our knowledge, this is the first time of the external magnet and HA-FA
actively induced synergistic effect tumor targeting systems based on NO
chemotherapy in vivo, serving as a new theranostic system.