Hollow S-Nitrosothiols Polymer Nanoparticles as Scaffolds for Nitric Oxide Release
作者：Tuanwei Liu, Wei Zhang, Xinlin Yang*, and Chenxi Li
關鍵字：Nanoparticles; S-Nitrosothiols; Nitric Oxide
論文來源：期刊
具體來源：J Colloid Interface Sci, 459 (1), 115-122 (2015). DOI: 10.1016/j.jcis.2015.08.011.
發表時間：2015年
This work reported the design,
preparation and characterization of functional hollow polymer nanoparticles
with S-nitrosothiol (SNO) as
scaffolds for nitric oxide (NO) release in PBS buffer and bovine serum. The
thiolated hollow polymer nanoparticles were prepared by distillation
precipitation polymerization of ethyleneglycol dimethacrylate (EGDMA) and
2-hydroxyethyl methacrylate (HEMA) in presence of
3-(methacryloxy)propyltrimethoxysilane (MPS)-modified silica as seeds and the
selective removal of silica core in hydrofluoric acid (HF) aqueous solution
together with the subsequent surface esterification of hydroxyl groups with
acryloyl chloride to introduce high density of vinyl groups and further Michael
addition of carbon-carbon double bonds with hydrosulfide (HS-)
anions. S-Nitrosothiol (SNO) functionalized hollow polymer
nanoparticles were prepared via nitrosation of the surface thiol groups with
acidified nitrite. The releasing characters of SNO-functionalized hollow
polymer nanoparticles as NO scaffolds with capacity of 1.55 mmol/mg were
investigated in different media, including PBS buffer exposure to trace copper
cations and in real bovine serum.