Advanced Functional Materials: Biodegradable Nanoparticles of Polyacrylic Acid Stabilized Amorphous CaCO3 for Tunable pH-Responsive Drug Delivery and Enhanced Tumor Inhibition
作者：Chengyuan Xu#, Yunfeng Yan#, Jinchao Tan, Dahai Yang, Xianjing Jia, Lu Wang, Yisheng Xu,* Song Cao,*
關鍵字：amorphous calcium carbonate, biodegradation, drug delivery, pH-responsive, tumor inhibition
論文來源：期刊
具體來源：Advanced Functional Materials
發(fā)表時間：2019年
Inorganic nanoparticles (NPs) are promising drug delivery carriers owing to
their high drug loading effciency, scalable preparation, facile functionalization, and chemical/thermal stability. However, the clinical translation of
inorganic nanocarriers is often hindered by their poor biodegradability and
lack of controlled pH response. Herein, a fully degradable and pH-responsive
DOX@ACC/PAA NP (pH 7.4–5.6) is developed by encapsulating doxorubicin
(DOX) in poly(acrylic acid) (PAA) stabilized amorphous calcium carbonate
(ACC) NPs. The DOX-loaded NPs have small sizes (62 ± 10 nm), good serum
stability, high drug encapsulation effciency (>80%), and loading capacity
(>9%). By doping proper amounts of Sr2+ or Mg2+, the drug release of NPs
can be further modulated to higher pH responsive ranges (pH 7.7–6.0), which
enables drug delivery to the specifc cell domains of tissues with a less acidic
microenvironment. Tumor inhibition and lower drug acute toxicity are further
confrmed via intracellular uptake tests and zebrafsh models, and the particles
also improve pharmacokinetics and drug accumulation in mouse xenograft
tumors, leading to enhanced suppression of tumor growth. Owing to the excellent biocompatibility, biodegradability, and tunable drug release behavior, the
present hybrid nanocarrier may fnd broad applications in tumor therapy.