Multifunctional Fluorinated Lubricant Infused Poly(4-hydroxybutyrate) (P4HB) Membranes for Full Thickness Abdominal Wall Defect Repair
writer：Xiuxia Sun, Qi Chen, Angelique A. Guan, Shuaishuai Yuan*, Zhibo Li*
keywords：hernia repair, nanofibrousmembranes, perfluorocarbon oil, peritoneal adhesions, poly(4-hydroxybutyrate) (P4HB)
source：期刊
specific source：Macromolecular Bioscience
Issue time：2023年
Abdominal wall defect caused by surgical trauma, congenital rupture, or
tumor resection may result in hernia formation or even death. Tension-free
abdominal wall defect repair by using patches is the gold standard to solve
such problems. However, adhesions following patch implantation remain one
of the most challenging issues in surgical practice. The development of new
kinds of barriers is key to addressing peritoneal adhesions and repairing
abdominal wall defects. It is already well recognized that ideal barrier
materials need to have good resistance to nonspecific protein adsorption, cell
adhesion, and bacterial colonization for preventing the initial development of
adhesion. Herein, electrospun poly(4-hydroxybutyrate) (P4HB) membranes
infused with perfluorocarbon oil are used as physical barriers. The oil-infused
P4HB membranes can greatly prevent protein attachment and reduce blood
cell adhesion in vitro. It is further shown that the perfluorocarbon oil-infused
P4HB membranes can reduce bacterial colonization. The in vivo study reveals
that perfluoro(decahydronaphthalene)-infused P4HB membranes can
significantly prevent peritoneal adhesions in the classic abdominal wall
defects’ model and accelerate defect repair, as evidenced by gross
examination and histological evaluation. This work provides a safe fluorinated
lubricant-impregnated P4HB physical barrier to inhibit the formation of
postoperative peritoneal adhesions and efficiently repair soft-tissue defects.