Fabrication of Bioresorbable Barrier Membranes from Gelatin/Poly(4-hydroxybutyrate) (P4HB)
writer：Shuaishuai Yuan, Qi Chen, Manman Guo, Yongzhi Xu, Wanchun Wang, Zhibo Li
keywords：Gelatin, poly(4-hydroxybutyrate), biodegradable, guided bone regeneration, electrospun membrane.
source：期刊
specific source：Macromolecular Bioscience
Issue time：2024年
Dental implant surgery is a procedure that replaces damaged or missing teeth with an artificial implant. During this procedure, guided bone regeneration (GBR) membranes were commonly used to inhibit the migration of epithelium and guided bone regeneration at the surgical sites. Due to its biodegradability, good biocompatibility, and unique biological properties, gelatin (GT) was considered a suitable candidate for guiding periodontal tissue regeneration. However, GT-based membranes come with limitations, such as poor mechanical strength and mismatched degradation rates. To confront this challenge, we fabricated a series of GT/poly(4-hydroxybutyrate) (P4HB) composite membranes through electrospinning technology. The morphology, composition, wetting properties, mechanical properties, biocompatibility, and in vivo biodegradability of the as-prepared composite membranes were carefully characterized. The results demonstrated that all the membranes present excellent biocompatibility. Moreover, the in vivo degradation rate of the membranes can be manipulated by changing the ratio of GT and P4HB. The results indicated that the optimized GT/P4HB membranes with a high P4HB content (75%) may be suitable for periodontal tissue engineering because of their good mechanical properties and biodegradation rate compatible with tissue growth.