Synthesis, Characterization, and Properties of Amphiphilic Chitosan Copolymers with Mixed Side Chains by Click Chemistry
writer：WEIZHONG YUAN, ZHENGDA ZHAO, SHUYING GU, JIE REN
keywords：chitosan, click chemistry, crystalline morphology, micelle, mixed side chain, self-assembly
source：期刊
Issue time：2010年
Novel amphiphilic chitosan copolymers with mixed
side chains of poly(e-caprolactone) and poly(ethylene oxide)
(CS-g-PCL/PEO) were successfully synthesized by ‘‘graft to’’
approach via click chemistry. The melting and crystallization
behaviors and crystalline morphology of CS-g-PCL/PEO copolymers
can be adjusted by the alteration of the feed ratio of PCL
and PEO segments. CS-g-PCL/PEO copolymers revealed crystalline
morphology different from that of linear alkynyl PCL
and alkynyl PEO due to the influence of brush structure of
copolymers and the mutual influence of PCL and PEO segments.
The hydrophilicity of the CS copolymers can be
improved and adjusted by the alteration of the composition ofPCL and PEO segments. Moreover, the CS copolymers can
self-assemble into spherical micelles in aqueous solution.
Investigation shows that the size of the CS copolymer micelles
increased with the increase of the content of hydrophobic
PCL segments in copolymers, which indicated that the
micellar behavior of the copolymers can be controlled by the
adjustment of the ratio of PCL and PEO segments in copolymer.