Thermo-sensitive composite microspheres incorporating cellulose nanocrystals for regulated drug release kinetics
作者：Mingchen Yang, Somia Yassin Hussain Abdalkarim, Hou-Yong Yu, Rabie A.M. Asad, Dan Ge,Ying ZHou
關鍵字：Poly(3-hydroxybutyrate-co-3-hydroxyvalerate),Cellulose nanocrystals,Polyethylene glycol,Composite microspheres,Thermo-sensitive,Drug release
論文來源：期刊
具體來源：doi.org/10.1016/j.carbpol.2022.120350
發表時間：2022年
Thermo-sensitive composite microspheres (TPCP) were developed to achieve the on-demand release of drugs.The TPCP microspheres were synthesized using Oil-in-Water (O/W) emulsion evaporation technique and then impregnated with thermo-sensitive polyethylene glycol (PEG). The addition of cellulose nanocrystals (CNCs) significantly enhance thermal stability, crystallization ability, and surface hydrophilicity of TPCP microspheres due to heterogeneous nucleation effect and hydrogen bonding interaction, resulting in stable microsphere structure. The thermal degradation temperature (Tmax) increased by 13.8 ?C, and the crystallinity improved by 20.9 % for 10 % TPCP. The thermo-sensitive composite microspheres showed the regulated cumulative release according to in vitro human physiological temperature changes. Besides, four release kinetics and possible release mechanism of TPCP microspheres were provided. Such thermo-responsive composite microspheres with control microsphere sizes and high encapsulation rate may have the potential to the development of on-demand and advanced controlled-release delivery systems.