[Macromol. Biosci.] Tailored Poly(2-oxazoline) Polymer Brushes to Control Protein Adsorption and Cell Adhesion
writer：Ning Zhang, Tilo Pompe,* Ihsan Amin, Robert Luxenhofer, Carsten Werner, Rainer Jordan*
keywords：oxazoline, bottle-brush brushes, bioadsorption
source：期刊
specific source：macromolecular bioscience
Issue time：2012年
POx bottle-brush brushes (BBBs) are synthesized by SIPGP of 2-isopropenyl-2-oxazoline and consecutive LCROP of 2-oxazolines on 3-aminopropyltrimethoxysilane-modified silicon substrates. The side chain hydrophilicity and polarity are varied. The impact of the chemical composition and architecture of the BBB upon
protein (fibronectin) adsorption and endothelial cell adhesion are investigated and prove extremely low protein adsorption and cell adhesion on BBBs with hydrophilic side chains such as poly(2-methyl-2-oxazoline) and poly(2-ethyl-2-oxazoline).
The influence of the POx side chain terminal function upon adsorption and adhesion is minor but the side chain length has a significant effect on bioadsorption.
http://onlinelibrary.wiley.com/doi/10.1002/mabi.201200026/abstract