[Chem. Commun.] Formal [4+1] annulation of α,α-dialkyl β-oxo amides and dimethylsulfoxonium methylide: a synthetic route to β-hydroxy-γ-lactams
writer：Dingyuan Zhang, Qian Zhang, Ning Zhang,* Rui Zhang, Yongjiu Liang and Dewen Dong*
keywords：lactam, Corey reagent, cyclization
source：期刊
Issue time：2013年
A facile and efficient one-pot synthesis of β-hydroxy-γ-lactams from α,α-dialkyl β-oxo amides and trimethylsulfoxonium iodide in the presence of sodium hydride via a tandem Corey–Chaykovsky reaction and an intramolecular lactamization process is developed.