[Org. Biomol. Chem.] [5C + 1N] Annulation of 2,4-pentadienenitriles with hydroxylamine: a synthetic route to multi-substituted 2-aminopyridines
作者：Xiaoqing Xin, Peng Huang, Dexuan Xiang, Rui Zhang,* Fengyu Zhao, Ning Zhang and Dewen Dong*
關(guān)鍵字：annulation, 2-aminopyridines, 2,4-pentadienenitriles
論文來(lái)源：期刊
具體來(lái)源：Org. Biomol. Chem.
發(fā)表時(shí)間：2013年
A facile and efficient synthetic route to multi-substituted 2-aminopyridines has been developed via a formal [5C + 1N] annulation of readily available 2,4-pentadienenitriles with hydroxylamine (NH2OH) under very mild conditions, which involves sequential intermolecular aza-nucleophilic addition of hydroxylamine, intramolecular aza-cyclization, and dehydration reactions.