作者：張黎明等//Zhang, L. M.; et al
關鍵字：天然大分子，生物大分子, 功能材料, 雜化材料 // Natural macromolecules, Biomacromolecules, Functional materials, Hybrid materials
論文來源：期刊
發表時間：2016年
*Corresponding author(s)/通訊作者. #These authors contributed equally to this work/共同第一作者.
Refereed Scientific Papers / 學術雜志發表論文
[309] Yin, Y. T.#; Fu, C. P.#; Li, M.; Li, X. P.; Wang, M. Y.; He, L.; Zhang, L. M.*; Peng, Y.* A pH-sensitive hyaluronic acid prodrug modified with lactoferrin for glioma dual-targeted treatment. Materials Science and Engineering C-Materials for Biological Applications, 2016, 67: 159-169. DOI: 10.1016/j.msec.2016.05.012 (SCI)
[308] Yang, H. K. #; Qi, M.#; Mo, L.; Yang, R. M.; Xu, X. D.; Bao, J. F.; Tang, W. J.; Lin, J. T.(林堅濤); Zhang, L. M.*; Jiang, X. Q.* Reduction-sensitive amphiphilic dextran derivatives as theranostic nanocarriers for chemotherapy and MR imaging. RSC Advances, 2016, 6:114519-114531. DOI: 10.1039/c6ra22373g (SCI)
[307] Liu, Y.#; Deng, L. Z.#; Sun, H. P.; Xu, J. Y.; Li, Y. M.; Xie, X.; Zhang, L. M.*; Deng, F. L.* Sustained dual release of placental growth factor-2 and bone morphogenic protein-2 from heparin-based nanocomplexes for direct osteogenesis. International Journal of Nanomedicine, 2016, 11: 1147-1158. DOI: 10.2147/ijn.s100156 (SCI)
[306] 劉日釗, 張娟, 劉濤, 符小藝, 張黎明, 謝民強*. 葉酸靶向共載TFPI-2及順鉑磁性納米復合物的制備及其對鼻咽癌HNE一1細胞的靶向性和體外抑制效應[Preparation of folate-targeted
magnetic nanocomposites loaded wjth TFPI-2 plasmid and cisplatin and evaluation
of its targeting and inhibitory effect on nasopharyngeal carcinoma HNE-1 cells in vitro]. 中華醫學雜志 / National
Medical Journal of China, 2016, 96(25), 2023-2030.
[305] 王芬*，龐家棟，張黎明. 多功能納米材料CDPF/CDP運載AEG-1 siRNA抑制骨肉瘤細胞增殖和侵襲能力的研究[EB/OL]. 北京：中國科技論文在線 / Chinese Science and Technology Papers online [2016-11-11]. http://www.paper.edu.cn/releasepaper/content/201611-169.
摘要：目的 探討多功能納米材料CDPF和CDP運載AEG-1 siRNA進入骨肉瘤細胞能力以及其對細胞增殖、侵襲能力的影響。方法 通過體外細胞瞬時轉染實驗將CDPF/AEG-1 siRNA或CDP/AEG-1 siRNA運載入143B細胞，用Western-blot檢測AEG-1 蛋白水平的變化，分別用MTT法和侵襲實驗檢測轉染復合物對143B細胞增殖能力和侵襲能力的影響。結果 CDPF和CDP成功的將AEG-1 siRNA運載至143B細胞，與對照組比較，AEG-1蛋白水平顯著降低，下調AEG-明顯抑制143B細胞的增殖和侵襲能力，且CDPF比CDP具有更好的優勢。結論 CDP可作為有效的新型基因轉染載體，葉酸的接入可提高其效率。