A pH gated, glucose-sensitive nanoparticle based on worm-like mesoporous silica for controlled insulin release.
writer：Lei Sun; Xinge Zhang*, Chao Zheng, Zhongming Wu, Chaoxing Li*
keywords：mesoporous silica , controlled drug release
source：期刊
specific source：The Journal of Physical Chemistry, Part B. 2013, in press.
Issue time：2013年
This study prepares a kind of core-shell hybrid nanoparticles, which is worm-like, pH gated, and glucose-sensitive. It has mesoporous silica nanoparticle (MSN) core and polymer shell (crosslinked and no-crosslinked), bearing 3-acrylamidophenylboronic acid (AAPBA) and N-isopropylacrylamide (NIPAM) as sensor moieties. The shell of nanoparticles has presented a distinct transition from swollen state to collapsed state as the temperature increases, which offers an easy access to drug loading. Here, insulin is applied as a model drug and the behaviors of its loading/release are investigated. Insulin loading is up to 15% via mesoporous silica core. In vitro experiment shows that the cumulative release of insulin is dependent on glucose concentration, and the glucose sensitivity could be adjusted simply by different pH values. Simultaneously, comparing with the no-crosslinked shell, the crosslinked shell, using dextran-maleic acid (Dex-Ma) as a macromolecule crosslink, enables insulin to release more persistently. Also, cell viability assay indicates that these nanoparticles have good biocompatibility. Consequently, the novel, pH gated, glucose-sensitive core-shell nanoparticles may have potential applications as a vehicle of self-regulated insulin delivery system.