Synthesis of an amphiphilic PEG-PCL-PSt-PLLA-PAA star quintopolymer and its self-assembly for pH-sensitive drug delivery
作者：Huanhuan Liu, Ke Miao, Guangdong Zhao,Cangxia Li and Youliang Zhao*
關(guān)鍵字：“l(fā)iving”/controlled polymerization, star polymer, drug delivery
論文來源：期刊
具體來源：Polym. Chem.
發(fā)表時(shí)間：2014年
http://pubs.rsc.org/en/content/articlelanding/2014/py/c3py01601c#!divAbstract
The synthesis and properties of a star quintopolymer comprising poly(ethylene glycol) (PEG, A), poly(ε-caprolactone) (PCL, B), polystyrene (PSt, C), poly(L-lactide) (PLLA, D), and poly(acrylic acid) (PAA, E) segments were described. Terminal diazide functionalized PEG (PEG-(N3)2), alkyne-mid-functionalized PCL-b-PSt and PLLA-b-PtBA diblock copolymers acted as building blocks to synthesize the target ABCDE star via modular synthesis. DSC analyses revealed that star copolymers usually exhibited complex chain relaxation and melting behaviors although arm segments were partly compatible. Various copolymers could self-assemble into vesicles (for ABC and ABCDE stars) and micelles (for the DE copolymer) in aqueous solution, and the release rate of doxorubicin from various aggregates at pH 7.4 decreased in the order DE > ABCDE star > ABC star. For the same types of aggregates, the increment in the cumulative amount at pH 5.3 for 72 h was 66.9% (for ABCDE vesicles) and 92.5% (for DE micelles), higher than that at pH 7.4 in the same period, revealing the remarkably accelerated release kinetics under acidic conditions. The ABCDE vesicles had great potential as controlled delivery vehicles due to their excellent stability, satisfactory drug loading efficiency, and pH-responsive drug release properties.
