Soochow University Biomedical Polymers Laboratory Publishes a Research Article in Angew. Chem. Int. Edit.
Reversibly Stabilized Multifunctional Dextran Nanoparticles Efficiently Deliver Doxorubicin into the Nuclei of Cancer Cells
Yu-Ling Li, Li Zhu, Zhaozhong Liu, Ru Cheng, Fenghua Meng*, Jing-Hao Cui, Shun-Jun Ji, and Zhiyuan Zhong*
Angew. Chem.-Int. Edit. 2009, 48, 9914-9918 (IF：10.879).
We have developed simple, biocompatible, and degradable multifunctional cross-linked dextran nanoparticles that are stable under extracellular conditions but are rapidly destabilized under reductive environments that mimic those of the intracellular compartments, such as the cytoplasm and the cell nucleus. These nanoparticles show high drugloading efficiency and reduction-triggered release of DOX in vitro as well as inside tumor cells, thus resulting in particularly efficient delivery and release of DOX to the cell nucleus. We are convinced that these smart nanoparticles have tremendous potential for tumor-targeted chemotherapy.