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Effect of branching architecture on the antifouling properties of PEG
writer:Chen, J. X.; Zhou, Y. F.*; Yan, D. Y.; Chen, D. Y.; Fang, J. J.; Yu, S. R.; Liu, Y.; Zhu, X. Y.
keywords:Antifouling, Hyperbranched, Degree of branching, Poly (ethylene glycol)
source:期刊
specific source:J. Control. Release 2013, 172, E147. http://www.sciencedirect.com/science/article/pii/S01683659130
Issue time:2013年
Protein-resistant surfaces are highly desirable in biomedical devices, implants, biosensors, and diagnostic arrays. Surface modifi-cations via thin polymer coatings represent an important tool to provide such antifouling properties. Poly(ethylene glycol) (PEG) has been used extensively for this purpose. Oligo(ethylene glycol) (OEG), star-shaped PEG, PEG-bearing block-copolymers and graft-copolymers have been employed as the antifouling coatings [1]. Despite the growing body of theoretical and experimental work on these materials, the influence of the molecular framework of PEG on the resistance of protein adsorption has never been reported.