The in vitro biocompatibility of self-assembled hyperbranched copolyphosphate nanocarriers
writer：Liu, J.Y.; Huang, W.*; Pang, Y.; Zhu, X. Y.; Zhou, Y. F.; Yan, D.Y.*
keywords：Polyphosphate, Nanocarrier, Self-assembly, Hyperbranched polymer, Biocompatibility
source：期刊
specific source：Biomaterials 2010, 31, 5643. http://www.sciencedirect.com/science/article/pii/S0142961210004527
Issue time：2010年
Polymeric micelles are recognized as very promising nanocarriers for
small-molecule drugs, DNA, and proteins delivery. Polyphosphates are an
important class of eminent biomaterials and widely used in biomedicine
due to their good biocompatibility, biodegradability, and flexibility in
adjusting the pendant structures. Here, some full-polyphosphate
nanocarriers have been constructed successfully through self-assembly of
amphiphilic hyperbranched multiarm copolymers (denoted as HPHEEP-star-PPEPs). The hydrophilic core and hydrophobic multiarm of HPHEEP-star-PPEPs are composed by hyperbranched and linear polyphosphates respectively. HPHEEP-star-PPEPs
can self-assembly into nanocarriers in aqueous media with controlled
size from 48 to 74 nm by conveniently adjusting the length of
hydrophobic arm. These nanocarriers possess excellent biocompatibility
against NIH 3T3 cells and are easily internalized by vivid cells.
Chlorambucil-loaded nanocarriers were investigated for proliferation
inhibition of an MDA-MB-231 breast cancer cell line in vitro, and the
chlorambucil dose required for 50% cellular growth inhibition was found
to be 3 μg/mL.