Facile Preparation of Novel Peptosomes through Complex Self-Assembly of Hyperbranched Polyester and Polypeptide,
writer：Guo, B.; Shi, Z. Q.; Yao, Y.; Zhou, Y. F.*; Yan, D. Y.*
keywords：Facile Preparation,Novel Peptosomes,Hyperbranched Polyester and Polypeptide
source：期刊
specific source：Langmuir 2009, 25, 6622. http://pubs.acs.org/doi/pdf/10.1021/la901366g
Issue time：2009年
This work reported for the first time a facile template-free method to
prepare polypeptide-based vesicles (peptosomes) through one-step complex
self-assembly of carboxyl-terminated hyperbranched polyester and
cationic poly-l-lysine (PLL). The
preparation of such peptosomes, named complex peptosomes (CPs) here, is
very simple just by mixing two kinds of polymer aqueous solutions
together. The CP size can be readily controlled from nanosize to
microsize through the adjustment of polymer concentration. The resulting
nanosized CPs show unexpected size stability independent of a broad
solution pH range, long-term storage stability, and almost no
cytotoxicity and have demonstrated great potential to be used as the
carriers in drug delivery.