Synthesis and Self-Assembly of Amphiphilic Aptamer-Functionalized Hyperbranched Multiarm Copolymers for Targeted Cancer Imaging
作者：Yu, S. R.; Dong, R. J.; Chen, J. X.; Chen, F.; Jiang, W. F.; Zhou, Y. F.*; Zhu, X. Y.*, Yan, D. Y.
關(guān)鍵字：Aptamer-Functionalized Hyperbranched Multiarm Copolymers
論文來源：期刊
具體來源：Biomacromolecules 2014, 15, 1828?1836.
發(fā)表時間：2014年
A novel targeting cancer imaging platform based on aptamer-functionalized amphiphilic hyperbranched copolymer conjugates, which can self-assemble into nanoscopic micelles with a core–shell structure and a narrow size distribution, has been designed and synthesized. The size, morphology, fluorescence performance, and cytotoxicity of micelles were studied by dynamic light scattering, transmission electron microscopy, fluorescence spectroscopy, and a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide colorimetric assay. The results indicate that these micelles have low cytotoxicity against MCF-7 cells and can be easily internalized by MCF-7 cells. In addition, they also exhibit enhanced cell uptake, excellent fluorescence properties, and smart targeting capability in vitro, indicating great potential to be promising carriers for bioimaging and cancer specific delivery.