| 簡(jiǎn) 介： |
Poly(L-lactide) (PLLA) nanofiber has attracted considerable attentions due to its potential application as a tissue engineering scaffold, but its poor thermal stability and mechanical properties restrict its applications. In this work, trially isocyanurate (TAIC) was added into PLLA solution at different ratios and fabricated into nanofibrous mats by electrospinning technique, the mats were then irradiated by gamma ray at different radiation doses to crosslink the PLLA chains. The thermal properties and biodegradation properties of different PLLA samples were investigated and compared. Furthermore, the in vitro biocompatibilities were also evaluated by using mouse L929 fibroblasts. The results indicated that the thermal stability and tensile mechanical properties were increased after crosslinking, and the crosslinked samples irradiated at 10 kGy exhibited the best enzymatic degradation. The in vitro results also revealed that the crosslinked PLLA/TAIC composite nanofibers did not induce cytotoxic effects and suitable for cell growth. Therefore, the crosslinked PLLA nanofibers are one of the promising materials for future tissue engineering applications. |
