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Folate-chitosan Modified Alginate/CaC03 Hybrid Nanoparticles for Tumor-targeted Drug Delivery

資料類型：

PDF文件

關(guān)鍵詞：

folic acid targeted drug delivery calcium carbonate
nanoparticles

資料大小：

102K

所屬學(xué)科：

分子表征

來源：

第六屆亞歐研討會(huì)上處理和性能增強(qiáng)聚合物會(huì)議文集（2013.6.2-6 武漢）

簡(jiǎn)介：

Folicacid(FA)isatargetinggroupwhichisextensivelyusedtodelivertherapeuticandimagingagentstofolatereceptor(FR)overexpressedcancercells.Inthisstudy,thealginate/calciumcarbonate(alginate/CaC03)hybridnanoparticleswithfolatemoietiesareappliedasthetargetinggroupsfortargeteddrugdelivery.Alginate/CaC03hybridnanoparticleswerepreparedbytheprecipitationofcalciumcarbonateintheaqueoussolutioncontainingalginatecl].Doxorubicinhydrochloride(DOX.HCI),awater-solubleanticancerdrug,wasloadedinthehybridnanoparticleswithahighencapsulationefficiency.Thefolicacidwasincorporatedtochitosan(CS)andthesynthesizedFA-CSconjugateswerecharacterizedwithFTIRandlHNMRc2].Toachievetumorcelltargetingproperty,FA-CSwasphysicallyincorporatedtoalginate/CaC03hybridnanoparticlescarryingDOX.HCI.TheobtainednanoparticleswerecharacterizedbySEM,FTIR,XPS,TGAandDSC.Thesizeandsizedistributionweremeasuredbyaparticlesizeanalyzer.Thereleasepropertydrugandthetargetingofthedrugloadednanoparticlestodifferentcellswereevaluatedinvitro.TheresultsshowedthatthereleaseofDOX.HCIfromthenanoparticlescouldbeeffectivelysustainedandthedrugloadednanoparticlesexhibitedenhancedcellinhibitionbecausefolatetargetingincreasedthecytotoxicityofdrugloadednanoparticlesagainstfolatereceptor(FR)expressingtumorcells.ItcanbeconcludedthattheincorporationofFA-CSphysicallytoalginate/CaC03nanoparticlescanobviouslyimprovethetargetingpropertyofthehybridsystems.

作者：

D. Zhao

上傳時(shí)間：

2013-07-03 15:13:02

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