研究方向
主要研究領(lǐng)域為生物醫(yī)用高分子材料的研究。針對人類面臨的健康問題，以現(xiàn)代物理及生物學技術(shù)為指導，主要運用自組裝等非傳統(tǒng)的制備技術(shù)，設(shè)計制備具有特定生物醫(yī)學應(yīng)用前景的高分子材料，如高分子自組裝薄膜、自組裝微膠囊、微凝膠、水凝膠等高分子生物材料。目前的主要研究課題有：
（1）葡萄糖敏感微凝膠/層層自組裝膜的設(shè)計、制備及其在胰島素可控釋放與葡萄糖傳感器領(lǐng)域的應(yīng)用。其中葡萄糖敏感微凝膠的研究獲得了國家自然科學基金的資助。
（2）新型聚合膠態(tài)晶體（生物）傳感器的研究。本項研究獲得了國家自然科學基金的資助。
（3）溫度敏感微凝膠溶液的實時膠凝及其用于可注射三維細胞支架材料的研究。本項研究獲得了國家科技部國際科技合作項目的資助。
近期代表作：
(1) Chen, M.; Zhang, Y; Jia, Y.; Zhou, L.; Guan, Y.; Zhang, Y.*, Photonic Crystals with a Reversibly Inducible and Erasable Defect State Using External Stimuli. Angew Chem Int Ed 2015, 54(32), 9257-9261.
(2) Chen, M.; Zhou, L.; Guan, Y.; Zhang, Y.*, Polymerized Microgel Colloidal Crystals: Photonic hydrogels with Tunable Bandgap and Fast Response Rate. Angew Chem Int Ed 2013, 52, (38), 9961-9965.
(3) Zhao, Y.; Yuan, Q.; Li, C.; Guan, Y.; Zhang, Y.*, Dynamic layer-by-layer films: a platform for zero-order release, Biomacromolecules 2015, 16(7), 2032-2039.
(4) Zhao, Z.; Gu, J.; Zhao, Y.; Guan, Y.; Zhu, X. X.; Zhang, Y.*, Hydrogel Thin Film with Swelling-Induced Wrinkling Patterns for High-Throughput Generation of Multicellular Spheroids. Biomacromolecules 2014, 15, (9), 3306-3312.
(5) Zhang, X.; Guan, Y.; Zhang, Y.*, Dynamically bonded layer-by-layer films for self-regulated insulin release. Journal of Materials Chemistry 2012, 22, (32), 16299-16305.
(6) Xing, S.; Guan, Y.; Zhang, Y.*, Kinetics of Glucose-Induced Swelling of P(NIPAM-AAPBA) Microgels. Macromolecules 2011, 44, (11), 4479-4486.
(7) Zhang, X.; Guan, Y.; Zhang, Y.*, Ultrathin Hydrogel Films for Rapid Optical Biosensing. Biomacromolecules 2012, 13, (1), 92-97.
(8) Gan, T.; Zhang, Y.*; Guan, Y., In Situ Gelation of P(NIPAM-HEMA) Microgel Dispersion and Its Applications as Injectable 3D Cell Scaffold. Biomacromolecules 2009, 10, (6), 1410-1415.
(9) Wang, D.; Cheng, D.; Guan, Y.; Zhang, Y.*, Thermoreversible Hydrogel for In Situ Generation and Release of HepG2 Spheroids. Biomacromolecules 2011, 12, (3), 578-584.
(10) Gan, T. T.; Guan, Y.; Zhang, Y.*, Thermogelable PNIPAM microgel dispersion as 3D cell scaffold: effect of syneresis. Journal of Materials Chemistry 2010, 20, (28), 5937-5944.
(11) Zhou, L.; Chen, M.; Guan, Y.; Zhang, Y.*, Multiple responsive hydrogel films based on dynamic Schiff base linkages. Polymer Chemistry 2014, 5, 7081-7089.
(12) Tang, Z.; Guan, Y.; Zhang, Y.*, Contraction-type glucose-sensitive microgel functionalized with a 2-substituted phenylboronic acid ligand. Polymer Chemistry 2014, 5, (5), 1782-1790.
