Tough and Biocompatible Hydrogels Based on in situ Interpenetrating Networks of Di-thiol-connected Graphene Oxide and Poly(vinyl alcohol)
writer：Gaolai Du, Lei Nie, Guorong Gao, Yuanna Sun, Ruixia Hou, Hua Zhang, Tao Chen, and Jun Fu*
keywords：hydrogel, PVA, graphene oxide, di-thiol
source：期刊
specific source：ACS Applied Materials and Interfaces, 2005, 7, 3003-3008.
Issue time：2015年
Interpenetrating network (IPN) strategy
has been widely facilitated to construct strong and tough hydrogels, but most
of the effects are focused on organic/organic parents. Herein, aqueous
dispersible 2, 2’-(ethylenedioxy)-diethanethiol (EDDET)
crosslinked graphene oxide (E-cGO) skeleton was in situ incorporated into PVA matrix,
resulting in novel inorganic/organic IPN hydrogels with super mechanical and
chondrocyte cell-adhesion properties. The unique interpenetrating structure and
hydrogen bonding were demonstrated to play critical roles in enhancing the
compressive property of the IPN hydrogels, in comparison to the GO and thermally reduced graphene oxide (T-rGO) filled
hydrogels. It is critical that the E-cGO/PVA hydrogels have been demonstrated
biocompatible, which provided the E-cGO/PVA hydrogels as promising candidate
biomaterials for load-bearing bio-tissue substitution.