A simple but efficient zwitterionization method towards cellulose membrane with superior antifouling property and biocompatibility
writer：Pan Wang,Jianqiang Meng,Mingli Xu,Tao Yuan
keywords：zwitterionic polymers
source：期刊
specific source：JOURNAL OF MEMBRANE SCIENCE
Issue time：2015年
Cellulose membrane has been widely used for
bioseparation and blood puri?cation but suffers from fouling issue and insuf?cient
biocompatibility. Surface grafting of zwitterions onto membrane surface can
effectively alleviate this issue. Current grafting methods are mostly based on
free radical polymerizations and have limitations of multi-step process, the
requirement of inert atmosphere and inevitable ?ux decline. Herein we put
forward a simple method for cellulose membrane (CM) zwitterionization. The modi?cation
was carried out via a one-step method based on the alkoxysilane condensation
reaction using three silane coupling agents including (3-carboxypropylbetaine-propyl)-trimethoxysilane(CPPT),(3-sulfopropylbetaine-propyl)-trimethoxysilane
(SPPT), and (3-sulfobutylbetaine-propyl)-trimethoxysilane (SBPT). Membrane
surfaces were characterized by ATR-FTIR, XPS, SEM, water contact angle (WCA)
and streaming potential. Membrane mechanical performance, pore size and its distributions
were measured. The antifouling property, hemocompatibility and
cytocompatibility of the membranes were evaluated by protein adsorption,
platelet adhesion, cell attachment and MTT assay experiments. The results show
that sulfobetaines and carboxybetaines were successfully grafted on the CM
surface. The obtained zwitterions-grafted membranes show excellent resistance
to protein adhesion, platelet adhesion and cell attachment. More importantly,
the biocompatibility of the CM membrane was retained.