[Biomacromolecules] Platinum-Containing Supramolecular Drug Self-Delivery Nanomicelles for Efficient Synergistic Combination Chemotherapy
writer：Chengfei Liu, Muqiong Li, Pengxiang Li, Wenzhuo Chen, Huixin Li, Li Fan,* and Wei Tian*
keywords：Supramolecular Drug Self-Delivery，Efficient Synergistic Combination Chemotherapy
source：期刊
specific source：Biomacromolecules 2021, 22, 2382-2392
Issue time：2021年
Supramolecular drug self-delivery systems(SDSDSs) involving active drugs as building blocks linked by supramolecular interactions have been well defined as an advanced chemotherapy strategy. However, the lack of detecting release of drugs from SDSDSs at specific tumor sites inevitably leads to unsatisfactory therapeutic effects, owing to the lack of information regarding the administration of these drugs. In this work, predesigned platinum-containing supramolecular drug self-delivery nanomicelles (SDSDNMs) were employed to synchronously realize drug monitoring by computed tomography imaging, immediately reflecting the evolution of drug release and real-time treatment at the tumor site. The appropriate administration dosage (1.2 mg mL-1,100 μL) and the injection interval (once every 3 days) needed to guide the antitumor activity of SDSDNMs were then defined, thereby attaining the aim of efficient synergistic combination chemotherapy. In vivo tumor inhibition and histological analyses showed that SDSDNMs exhibited a strong tumor inhibition effect and good safety with respect to normal organs. Such a supramolecular drug self-delivery strategy with monitored functions may offer new potential opportunities for application in the field of synergistic combination chemotherapy.
全文鏈接：
https://doi.org/10.1021/acs.biomac.1c00173