[Chem. Commun] Reversible morphology transitions of supramolecular polymer self-assemblies for switch-controlled drug release
writer：Haitao Zhang, Xiaodong Fan,* Rongtian Suo, Hui Li, Zhen Yang, Wanbin Zhang, Yang Bai, Hao Yao and We
keywords：the reversible morphology transitions,switch-controlled drug release
source：期刊
specific source：Chem. Commun.,2015,51, 15366-15369
Issue time：2015年
A novel method for switch-controlled drug release was developed through the reversible morphology transitions of supramolecular branched copolymer self-assemblies. The reversible transitions from vesicles to nanoparticles were successfully achieved by alternating UV and visible light irradiation to obtain morphology-controlled drug release in a switch mode.
In this study, we present a switch-controlled drug release system through light-triggered reversible morphology transitions of supramolecular self-assemblies from vesicles to nanoparticles on the basis of the destruction and reconstruction of a supramolecular branched copolymer (2(mPEG)-g-(PDEA-b-PEG-b-PDEA)-g-2(mPEG),
SBCP; Scheme 1a). SBCP was synthesized through the orthogonal self-assembly of poly((diethylamino)ethyl-methacrylate)-b-polyethyleneglycol- b poly((diethylamino)ethyl-methacrylate) containing two b-CD units at every terminal ((b-CD)2-g-(PDEA-b-PEG-b-PDEA)- g-(b-CD)2, P1) and methoxypolyethyleneglycols with single trans-Azo end-capping (mPEG-tAzo, P2). SBCP self-assembled into vesicles when the pH of the polymer solution was increased from 6.0 to 7.4. Doxycycline (DOX) molecules as a model drug were synchronously encapsulated into the vesicles (Scheme 1a and b). After alternating UV/visible light irradiation, the host–guest interactions between the b-CD and Azo groups in SBCP self-assemblies underwent reversible dissociation–association and led to the reversible morphology transitions from vesicles to nanoparticles (Scheme 1b–d and d–b) accompanied by the controlled release of DOX in an on–off switch mode.
全文鏈接：http://pubs.rsc.org/en/Content/ArticleLanding/2015/CC/C5CC05579B#!divAbstract