[Polym.Chem.]PGMA-based supramolecular hyperbranched polycations for gene delivery
writer：Miao Qi,+a Shun Duan,+b,c Bingran Yu,c Hao Yao,a Wei Tian*a and Fu-Jian Xu*b,c
keywords：gene delivery, (PGMA)-armed AB2 type macromonomers, supramolecular hyperbranched polymers
source：期刊
specific source：Polym. Chem., 2016, 7, 4334-4341
Issue time：2016年
Supramolecular chemistry has been widely applied in biomedical fields. It was reported that the topological structure has effects on the performance of gene delivery systems. Supramolecular polymer-like gene carriers with hyperbranched topological structures have still not been reported. In this work, a series of ethanolamine functionalized polyglycidyl methacrylate (PGMA)-armed AB2 type macromonomers were synthesized based on atom transfer radical polymerization. The AB2 type macromonomers can selfassemble into supramolecular hyperbranched polymers by the host–guest interaction between adamantane and β-cyclodextrin. The biophysical properties of self-assembled and dissembled supramolecular hyperbranched polycations were evaluated in detail. The self-assembled supramolecular polycations with hyperbranched structures possessed higher pDNA condensation ability and much better gene transfection performances than the dissembled AB2 type counterparts. The present work would provide a new venue for designing advanced high-performance supramolecular hyperbranched nucleic acid-delivery systems.
全文鏈接：http://pubs.rsc.org/en/Content/ArticleLanding/2016/PY/C6PY00759G#!divAbstract