Efficient One-Pot Synthesis of Water-Compatible Molecularly Imprinted Polymer Microspheres by Facile RAFT Precipitation Polymerization
writer：Guoqing Pan, Ying Zhang, Yue Ma, Chenxi Li, Huiqi Zhang*
keywords：Water-Compatible, Molecularly imprinted polymers, RAFT precipitation polymerization
source：期刊
specific source：Angew. Chem. Int. Ed. 2011, 50, 11731-11734.
Issue time：2011年
In this manuscript, we report a new and efficient one-pot approach to obtain pure-water-compatible and narrowly dispersed MIP microspheres with surface-grafted hydrophilic polymer brushes by facile reversible addition/fragmentation chaintransfer (RAFT) precipitation polymerization (RAFTPP), mediated by hydrophilic macromolecular chain-transfer agents (Macro-CTAs). The presence of hydrophilic polymer brushes on MIP microspheres significantly improved their surface hydrophilicity and dramatically reduced their hydrophobic interactions with template molecules in pure aqueous media, thus leading to their water compatibility. The easy availability of many different hydrophilic Macro-CTAs (by either RAFT polymerization of hydrophilic monomers or hydrophilic polymer end group modification), together with the versatility of RAFTPP for the controlled preparation of MIP microspheres, makes this strategy highly applicable for the design of hydrophilic and water-compatible MIPs.