One-Pot Synthesis of Surface-Functionalized Molecularly Imprinted Polymer Microspheres by Iniferter-Induced "Living" Radical Precipitation Polymerization
writer：Junyi Li, Baiyi Zu, Ying Zhang, Xianzhi Guo, Huiqi Zhang*
keywords：Molecularly imprinted polyemrs, microspheres, one-pot synthesis, iniferter-induced "living" radical precipitation polymerization
source：期刊
specific source：J Polym Sci, Part A: Polym Chem 2010, 48(15), 3217-3228.
Issue time：2010年
This article describes for the first time the development of a new polymerization technique by introducing iniferter-induced "living" radical polymerization mechanism into precipitation polymerization and its application in the molecular imprinting field. The resulting iniferter-induced "living" radical precipitation polymerization (ILRPP) has proven to be an effective approach for generating not only narrow disperse poly(ethylene glycol dimethacrylate) microspheres but also molecularly imprinted polymer (MIP) microspheres with obvious molecular imprinting effects towards the template (a herbicide 2,4-dichlor-ophenoxyacetic acid (2,4-D)), rather fast template rebinding kinetics, and appreciable selectivity over structurally related compounds. The binding association constant K-a and apparent maximum number N-max for the high-affinity sites of the 2,4-D imprinted polymer were determined by Scatchard analysis and found to be 1.18 x 10(4) M-1 and 4.37 mu mol/g, respectively. In addition, the general applicability of ILRPP in molecular imprinting was also confirmed by the successful preparation of MIP microspheres with another template (2-chloromandelic acid). In particular, the living nature of ILRPP makes it highly useful for the facile one-pot synthesis of functional polymer/MIP microspheres with surface-bound iniferter groups, which allows their direct controlled surface modification via surface-initiated iniferter polymerization and is thus of great potential in preparing advanced polymer/MIP materials.