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Figure 1. (a) The formation of a MNP. (b) The glucose-responsive insulin-releasing mechanism and the corresponding influence factors. (c) The illustration for the blood-glucose regulating performance of a MNP.

Figure 2. The cumulative-releasing tests for FITC-INS-loaded (a) MNP-1, (b) MNP-2, (c) MNP-3, (d) MNP-4, (e) MNP-5 and (f) MNP-6. (g) The comparison result among MNP-i and the previously reported phenylborate-ester-crosslinked MNPs. (h) The INS-releasing performance of MNP-5 under the changing glucose concentrations. (i) The 11B spectra to study the formation of phenylborate esters. (j) The formation of the phenylborate esters. The data of (a)-(f) and (h) were shown as the means ï¿½ï¿½ SD (n = 3).

Figure 3. (a₁) A piece of GR-MNP was inserted in the rat skin and fixed by the Tegaderm^TM film. (a₂) The photos of the microneedle-induced micro-pores (scale bar = 2 mm) and the trypan-blue-staining result. (a₃) The H & E-staining section of the microneedle-inserted skin (scale bar = 50 ï¿½ï¿½m). (b) The anti-hypoglycemia test on the healthy rats and (c) the corresponding analytic result. (d) The BGL-lowering test on the diabetic rats and (e) the corresponding plasma INS levels. (f) The IPGTT schedule, (g) the IPGTT results and (h) the corresponding analytic result. (i) The plasma-INS curves in IPGTT with the statistical analysis between ï¿½ï¿½nGR-MNPï¿½ï¿½ and ï¿½ï¿½GR-MNPï¿½ï¿½ and (j) the corresponding analytic result. (k) The BGL-controlling test under the mimic three-meal-per-day mode. All the data of (b)-(e) and (g)-(k) were shown as the means ï¿½ï¿½ SD (n = 5). The statistical analyses were performed by two-tailed Studentï¿½ï¿½s t-test. * P < 0.05, ** P < 0.01 and *** P < 0.001.

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Õ“ï¿½ï¿½ï¿½ï¿½Ï¢ï¿½ï¿½ACS Appl. Mater. Interfaces 2024, 16, 4449-4461

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