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  �ذl�Է��w�S�� (idiopathic pulmonary fibrosis, IPF)�����M���Ե��g�|�Էβ������г��m�ķι��ܓp��^[2]��Ŀǰȫ��s��500�f�˻���IPF��ƽ����λ�����ڞ�3-5��^[3]��Ȼ�������ֹ������ˎ��H��������ͪ�����_�᲼���Ҟ�FDA�����]ˎ����ھ޴�δ�M����R������^{[4, 5]}��

  2022��6��22�գ��Ϻ���ͨ��Wˎ�WԺ��ѩ����ڈF�“�����������WԺ�S��ꖽ����F���Science Advances�ϰl�����}��Inhaled siRNA nanoparticles targeting IL11 inhibit lung fibrosis and improve pulmonary function post-bleomycin challenge���о�Փ�ġ����ڿ�����ĺ���{���f���d�w���ɹ��f��С�ɔ_RNA��siRNA�����_�w�S��С��ķβ������F���w�S�����ί����Ϻ���ͨ��W������ʿ��ԓՓ�ĵĵ�һ���ߣ��Ϻ���ͨ��Wˎ�WԺ���һ��ͨӍ��λ��

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  1, X. Bai, G. L. Zhao, Q. J. Chen, Z. Y. Li, M. Z. Gao, W. Ho, X. Y. Xu, X.-Q. Zhang, Inhaled siRNA nanoparticles targeting IL11 inhibit lung fibrosis and improve pulmonary function post-bleomycin challenge. Sci. Adv. 8, eabn7162 (2022).

  2, R. Sharif, Overview of idiopathic pulmonary fibrosis (IPF) and evidence-based guidelines. Am. J. Manag. Care 23, S176�CS182 (2017).

  3, E. Farrand, C. Iribarren, E. Vittinghoff, T. Levine-Hall, B. Ley, G. Minowada, H. R. Collard, Impact of idiopathic pulmonary fibrosis on longitudinal health-care utilization in a community-based cohort of patients. Chest 159, 219�C227 (2021).

  4, G. Raghu, W. C. Johnson, D. Lockhart, Y. Mageto, Treatment of idiopathic pulmonary fibrosis with a new antifibrotic agent, pirfenidone: Results of a prospective, open-label phase II study. Am. J. Respir. Crit. Care Med. 159, 1061�C1069 (1999).

  5, M. Myllarniemi, R. Kaarteenaho, Pharmacological treatment of idiopathic pulmonary fibrosis - preclinical and clinical studies of pirfenidone, nintedanib, and N-acetylcysteine. Eur. Clin. Respir. J. 2 (2015).

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